INTERLEUKIN-16 AND THROMBOPOIETIN: NEW TOOLS FOR THE IN VITRO GENERATION OF DENDRITIC CELLS? running headline: dendritic cells generation and IL-16
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word count: 173 Total text word count: 4805 Blood First Edition Paper, prepublished online August 10, 2004; DOI 10.1182/blood-2004-03-0885 Copyright © 2004 American Society of Hematology For personal use only. on August 16, 2017. by guest www.bloodjournal.org From
منابع مشابه
Are interleukin-16 and thrombopoietin new tools for the in vitro generation of dendritic cells?
The effects of interleukin 16 (IL-16) on dendritic cell (DC) generation from human CD34(+) progenitor cells are not known. Here, we show that IL-16 added to a basal cocktail comprised of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-4, Flt-3 ligand (Flt3L), and tumor necrosis factor alpha (TNF-alpha) does induce the CD34(+) hematopoietic cells to proliferate in vitro and to diff...
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Current in vitro culture systems allow the generation of human dendritic cells (DCs), but the output of mature cells remains modest. This contrasts with the extensive amplification of hematopoietic progenitors achieved when culturing CD34(+) cells with FLT3-ligand and thrombopoietin. To test whether such cultures contained DC precursors, CD34(+) cord blood cells were incubated with the above cy...
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